Is it o.k. to lock the mosque if drunk people are going in?

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Check below answers in case you are looking for other related questions:
Ruling on a menstruating woman entering rooms etc. attached to the mosque
Mobile phones making haraam sounds

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Related Answers:
What is the reason why the grave of the Prophet (peace and blessings of Allaah be upon him) was incorporated into the mosque?
The mahr of al-hoor al-‘iyn
Ruling on placing a screen in the mosque in front of the worshippers
Ruling on a menstruating woman entering rooms etc. attached to the mosque
Mobile phones making haraam sounds

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